CEREBRAL AMYLOID IN MICE WITH CREUTZFELDT-JAKOB DISEASE IS INFLUENCED BY THE STRAIN OF THE INFECTIOUS AGENT

被引：6

作者：

KITAMOTO, T

YI, R

MOHRI, S

TATEISHI, J

机构：

[1] KYUSHU UNIV 60,FAC MED,INST NEUROL,DEPT NEUROPATHOL,HIGASHI KU,FUKUOKA 812,JAPAN

[2] KYUSHU UNIV 60,CTR LAB ANIM,FUKUOKA 812,JAPAN

来源：

BRAIN RESEARCH | 1990年 / 508卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

Agent strain; Amyloid; Creutzfeldt-Jakob disease; Infectious agent; Mouse; Prion protein;

D O I：

10.1016/0006-8993(90)91132-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined Fukuoka-1 and Fukuoka-2 mouse-adapted Creutzfeldt-Jakob disease strains. Mice infected with the Fukuoka-2 strain have a higher incidence of kuru plaques, a higher concentration of proteinase-resistant prion protein, and a higher infectivity titer than do mice with the Fukuoka-1 strain. Thus, it must be kept in mind that there is a difference in the strain of the infectious agent in murine Creutzfeldt-Jakob disease. © 1990.

引用

页码：165 / 167

页数：3

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