FEATURES OF HEPATIC ENZYME-INDUCTION WITH GLUTETHIMIDE IN MAN

被引：19

作者：

JACKSON, L ^{[1
]}

HOMEIDA, M ^{[1
]}

ROBERTS, CJC ^{[1
]}

机构：

[1] UNIV BRISTOL,DEPT PHARMACOL,BRISTOL BS8 1TD,AVON,ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1978年 / 6卷 / 06期

关键词：

D O I：

10.1111/j.1365-2125.1978.tb00877.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 Sequential measurements of D‐glucaric acid excretion were made in six healthy volunteers before, during and after 3 weeks' daily medication with glutethimide 500 mg. 2 There was a rapid rise in D‐glucaric acid excretion within 2 days of starting medication and a rapid decline when it was stopped. 3 Antipyrine clearance and indocyanine green clearance were measured before and at the end of the 3 weeks' medication. 4 There was a 55% increase in antipyrine clearance but no change in indocyanine green clearance. 5 There was no correlation between antipyrine clearance and D‐glucaric acid excretion. 6 Glutethimide causes rapid enzyme induction in man without concomitant rise in hepatic blood flow. 1978 The British Pharmacological Society

引用

页码：525 / 528

页数：4

共 25 条

[1] EVIDENCE FOR FUNCTION OF D-GLUCARIC ACID AS AN INDICATOR FOR DRUG INDUCED ENHANCED METABOLISM THROUGH GLUCURONIC ACID PATHWAY IN MAN [J].

AARTS, EM .

BIOCHEMICAL PHARMACOLOGY, 1965, 14 (03) :359-&

[2]

BRANCH RA, 1973, J PHARMACOL EXP THER, V187, P133

[3] INCREASED CLEARANCE OF ANTIPYRINE AND D-PROPRANOLOL AFTER PHENOBARBITAL TREATMENT IN MONKEY - RELATIVE CONTRIBUTIONS OF ENZYME-INDUCTION AND INCREASED HEPATIC BLOOD-FLOW [J].

BRANCH, RA ;

SHAND, DG ;

WILKINSON, GR ;

NIES, AS .

JOURNAL OF CLINICAL INVESTIGATION, 1974, 53 (04) :1101-1107

[4] CLINICAL IMPLICATIONS OF ENZYME INDUCTION [J].

BRECKENRIDGE, A ;

ORME, M .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1971, 179 (JUL6) :421-+

[5]

BRODIE BB, 1949, J BIOL CHEM, V179, P25

[6]

CAESAR J, 1961, CLIN SCI, V21, P43

[7] INDOCYANINE GREEN - OBSERVATIONS ON ITS PHYSICAL PROPERTIES, PLASMA DECAY, AND HEPATIC EXTRACTION [J].

CHERRICK, GR ;

STEIN, SW ;

LEEVY, CM ;

DAVIDSON, CS .

JOURNAL OF CLINICAL INVESTIGATION, 1960, 39 (04) :592-600

[8]

CONNEY AH, 1967, PHARMACOL REV, V19, P317

[9] EFFECT OF PHENOBARBITAL AND GLUTETHIMIDE ON BIOLOGICAL HALF-LIFE OF WARFARIN [J].

CORN, M .

THROMBOSIS ET DIATHESIS HAEMORRHAGICA, 1966, 16 (3-4) :606-&

[10]

CURRY SH, 1971, CLIN PHARMACOL THER, V12, P849

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