FEATURES OF HEPATIC ENZYME-INDUCTION WITH GLUTETHIMIDE IN MAN

被引:19
作者
JACKSON, L [1 ]
HOMEIDA, M [1 ]
ROBERTS, CJC [1 ]
机构
[1] UNIV BRISTOL,DEPT PHARMACOL,BRISTOL BS8 1TD,AVON,ENGLAND
关键词
D O I
10.1111/j.1365-2125.1978.tb00877.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1 Sequential measurements of D‐glucaric acid excretion were made in six healthy volunteers before, during and after 3 weeks' daily medication with glutethimide 500 mg. 2 There was a rapid rise in D‐glucaric acid excretion within 2 days of starting medication and a rapid decline when it was stopped. 3 Antipyrine clearance and indocyanine green clearance were measured before and at the end of the 3 weeks' medication. 4 There was a 55% increase in antipyrine clearance but no change in indocyanine green clearance. 5 There was no correlation between antipyrine clearance and D‐glucaric acid excretion. 6 Glutethimide causes rapid enzyme induction in man without concomitant rise in hepatic blood flow. 1978 The British Pharmacological Society
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页码:525 / 528
页数:4
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