Taking full account of the synergistic effects of multidimensional factors on regional economic growth in China, this paper constructs a model of the spatial spillover effects of transport infrastructure on regional economic growth. Using provincial panel data from 1993 to 2009 and employing spatial econometric techniques, our empirical analysis comes to the following conclusions. (1) The total output elasticity of transport infrastructure for regional economic growth varies between 0.05 and 0.07, indicating its important role in such growth. (2) Transport infrastructure has very clear spatial spillover effects on regional economic growth; its role in regional economic growth will be overestimated if these are neglected. (3) For a specific region, transport infrastructure in other regions has mainly positive spillover effects on economic growth, but there is also evidence of negative spillover effects. (4) Among multidimensional factors contributing to regional economic growth, labor plus capital stock from other parts of the public sector make the greatest contribution to regional economic growth in China, followed by the new economic growth factors and new economic geography.