AMINOCYCLANOLS .2. STEREOCHEMICAL STUDIES ON A NEW CIRAMADOL ANALOG BY NMR-SPECTROSCOPY

被引：1

作者：

BURGEMEISTER, T

OZARSLAN, O

ERTAN, M

AKGUN, H

WIEGREBE, W

机构：

[1] HACETTEPE UNIV,FAC PHARM,DEPT PHARMACEUT CHEM,ANKARA 06100,TURKEY

[2] MIDDLE EAST TECH UNIV,DEPT CHEM,ANKARA 06530,TURKEY

来源：

ARCHIV DER PHARMAZIE | 1994年 / 327卷 / 12期

关键词：

D O I：

10.1002/ardp.19943271206

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The absol. configuration of a Ciramadol analogue obtained from (-)-menthone is established by H-1-NMR-, simulated NMR-, COSY-90-, and NOE-measurements. The final compound 2-(alpha-1-pyrrolidino)benzyl-4-isopropyl-1-methyl-cyclohexan-3-one (4b), e.g., has 1R,2S,4S,11S-configuration due to stereoselective Michael-type addition of pyrrolidine to the pertinent benzylidene intermediate 3.

引用

页码：785 / 787

页数：3