GENETIC-LINKAGE STUDIES MAP THE MULTIPLE ENDOCRINE NEOPLASIA TYPE-2 LOCI TO A SMALL INTERVAL ON CHROMOSOME 10Q11.2

被引：100

作者：

GARDNER, E

PAPI, L

EASTON, DF

CUMMINGS, T

JACKSON, CE

KAPLAN, M

LOVE, DR

MOLE, SE

MOORE, JK

MULLIGAN, LM

NORUM, RA

PONDER, MA

REICHLIN, S

STALL, G

TELENIUS, H

TELENIUSBERG, M

TUNNACLIFFE, A

PONDER, BAJ

机构：

[1] UNIV CAMBRIDGE,DEPT PATHOL,CANC RES CAMPAIGN HUMAN CANC GENET RES GRP,CAMBRIDGE CB2 1QP,ENGLAND

[2] UNIV FLORENCE,DEPT CLIN PHYSIOPATHOL,MED GENET SECT,I-50144 FLORENCE,ITALY

[3] INST CANC RES,DIV EPIDEMIOL,SUTTON SM2 5NG,ENGLAND

[4] HENRY FORD HOSP,GENET RES LAB,DETROIT,MI 48202

[5] TUFTS UNIV MED,NEW ENGLAND MED CTR,DIV ENDOCRINOL,BOSTON,MA 02111

[6] KAROLINSKA INST,DEPT CLIN GENET,S-10401 STOCKHOLM 60,SWEDEN

[7] UAE UNIV,DEPT MED,AL AIN,U ARAB EMIRATES

来源：

HUMAN MOLECULAR GENETICS | 1993年 / 2卷 / 03期

关键词：

D O I：

10.1093/hmg/2.3.241

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have carried out genetic linkage analyses using fifteen polymorphic loci in the pericentromeric region of chromosome 10 in families with the inherited cancer syndromes multiple endocrine neoplasia (MEN) type 2A or 2B. A highly polymorphic microsatellite from the locus D10S141 in q11.2 was found to be recombinant with respect to the disease locus in two individuals and defines a new proximal flanking marker for both MEN2A and 2B. An additional recombination provides evidence that the locus D10S94, also in q11.2, is the closest distal flanking marker for MEN2A. This localises the MEN2A gene to a small region of 10q11.2 flanked by the loci D10S141 and D10S94, which are separated by a sex-averaged genetic distance of 0.55 cM. The MEN2B gene maps to a larger region, flanked by D10S141 and RBP3.

引用

页码：241 / 246

页数：6

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