EXPRESSION OF P-GLYCOPROTEIN IN RELATION TO CLINICAL MANIFESTATION, TREATMENT AND PROGNOSIS OF ADRENOCORTICAL CANCER

被引：22

作者：

HAAK, HR

VANSETERS, AP

MOOLENAAR, AJ

FLEUREN, GJ

机构：

[1] LEIDEN UNIV HOSP,DEPT ENDOCRINOL,2333 AA LEIDEN,NETHERLANDS

[2] LEIDEN UNIV HOSP,DEPT PATHOL CHEM,2333 AA LEIDEN,NETHERLANDS

[3] LEIDEN UNIV HOSP,DEPT PATHOL,2333 AA LEIDEN,NETHERLANDS

来源：

EUROPEAN JOURNAL OF CANCER | 1993年 / 29A卷 / 07期

关键词：

D O I：

10.1016/S0959-8049(05)80219-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The presence of P-glycoprotein, associated with multiple drug resistance and present in the normal adrenal cortex, was studied in 15 cases of adrenocortical carcinoma. P-glycoprotein was found in eight tumours; no correlation was found with clinical presentation, steroid production or histological index. 10 patients received mitotane. Remarkably, 3 patients with P-glycoprotein-positive tumours achieved complete remission. On the other hand, 2 patients with P-glycoprotein-negative tumours showed progression of the disease despite mitotane treatment. These findings suggest that the expression of P-glycoprotein in adrenocortical carcinoma is not related to clinical manifestations, steroid production, histological index or response to mitotane therapy.

引用

页码：1036 / 1038

页数：3

共 15 条

[1] MITOTANE ENHANCES CYTOTOXICITY OF CHEMOTHERAPY IN CELL-LINES EXPRESSING A MULTIDRUG RESISTANCE GENE (MDR-1/P-GLYCOPROTEIN) WHICH IS ALSO EXPRESSED BY ADRENOCORTICAL CARCINOMAS [J].