POPOLOHUANONE-E, A TOPOISOMERASE-II INHIBITOR WITH SELECTIVE LUNG-TUMOR CYTOTOXICITY FROM THE POHNPEI SPONGE DYSIDEA SP

被引：53
作者：
CARNEY, JR [1 ]
SCHEUER, PJ [1 ]
机构：
[1] UNIV HAWAII, DEPT CHEM, HONOLULU, HI 96822 USA
来源：
TETRAHEDRON LETTERS | 1993年 / 34卷 / 23期
关键词：
D O I：
10.1016/S0040-4039(00)79211-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An oxidatively-dimerized arenarol derivative, popolohuanone E (1), was isolated from a Pohnpei sponge. The compound is a potent inhibitor of topoisomerase-II and shows selective cytotoxicity against the A549 non-small cell human lung cancer cell line.
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收藏
页码：3727 / 3730
页数：4
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