2-OXOCEPHEMS - SYNTHESIS AND PROPERTIES OF 7-ACYLAMINO-2-OXOCEPHEM-4-CARBOXYLIC ACIDS

被引：13
作者：
ERNEST, I
机构：
[1] Woodward Research Institute, Basel
来源：
HELVETICA CHIMICA ACTA | 1979年 / 62卷 / 08期
关键词：
D O I：
10.1002/hlca.19790620818
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A synthesis of (6 R, 7 R)‐7‐acylamino‐2‐oxocephem‐4‐carboxylic acids from penicillins is reported based on the formation of the 2‐oxocephem system in an intramolecular Wittig condensation. An interesting steric effect of the acylamino grouping on the course of this key step was used to advantage. Some physical and biological properties of this new type of Δ3‐cephem are described. Copyright © 1979 Verlag GmbH & Co. KGaA, Weinheim
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页码：2681 / 2694
页数：14
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