Total synthesis of cajanine and its antiproliferative activity against human hepatoma cells

被引：28
作者：
Ji, Xing-yue
Xue, Si-tu
Zheng, Guang-hui
Han, Yan-xing
Liu, Zong-ying
Jiang, Jian-dong
Li, Zhuo-rong [1 ]
机构：
[1] Chinese Acad Med Sci, Inst Med Biotechnol, Dept Med Chem, Beijing 100050, Peoples R China
来源：
ACTA PHARMACEUTICA SINICA B | 2011年 / 1卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Total synthesis; Cajanine; Longistyline A; Antiproliferative activity;
D O I：
10.1016/j.apsb.2011.06.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cajanine, a constituent of Cajanaus cajan L., used in traditional Chinese medicine, is a promising drug candidate because of its broad range of bioactivities. However, the total synthesis of cajanine and its derivatives has never been reported. Herein, we report the total synthesis of cajanine in nine steps with an overall yield of 10% together with its analog, longistyline A, in 8 A yield. The antiproliferative activity of the two compounds against a human hepatoma cell line is also reported. (C) 2011 Institute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association. Production and hosting by Elsevier B.V. All rights reserved.
引用
收藏
页码：93 / 99
页数：7
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