ACUTE COCAINE ADMINISTRATION - EFFECTS ON LOCAL CEREBRAL BLOOD-FLOW AND METABOLIC DEMAND IN THE RAT

被引：42

作者：

SHARKEY, J

MCBEAN, DE

KELLY, PAT

机构：

[1] Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland

来源：

BRAIN RESEARCH | 1991年 / 548卷 / 1-2期

关键词：

COCAINE; PSYCHOSTIMULANT; CEREBRAL GLUCOSE UTILIZATION; CEREBRAL BLOOD FLOW; STROKE;

D O I：

10.1016/0006-8993(91)91138-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Local cerebral blood flow and glucose utilisation were measured in both saline (n = 10) and cocaine (10 mg/kg; n = 10) treated rats using [C-14]iodoantipyrine and [C-14]2-deoxyglucose quantitative autoradiography respectively. In control animals, the ratio of flow to metabolism was 1.40 (r = 0.92) for the 40 brain regions examined. Cocaine treatment altered neither the correlation (r = 0.83) nor the ratio (1.49). Thus, the fundamental relationship between CBF and metabolism remains intact following acute cocaine exposure.

引用

页码：310 / 314

页数：5