AMORPHOUS-TO-CRYSTALLINE TRANSFORMATION OF SUCROSE

被引：49
|
作者：
CARSTENSEN, JT [1 ]
VANSCOIK, K [1 ]
机构：
[1] ABBOTT LABS,N CHICAGO,IL 60064
来源：
PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 12期
关键词：
amorphous sucrose; amorphous–crystalline transformation; crystalline sucrose; rubbery state; sucrose;
D O I：
10.1023/A:1015942022789
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The transformation of amorphous sugar in the form of lyophilized spheres into crystalline sucrose was studied. The lyophilisate, when exposed to moist atmospheres, picks up moisture to a constant weight. The amount of moisture addition is a function of relative humidity of the atmosphere and temperature. The loose “lyophilisate structure” collapses to form a denser amorphous phase (“hydrated amorphate”). After a lag time which varies with relative humidity of the atmosphere and temperature, the hydrated amorphate loses moisture (weight) and, in the process, forms crystalline sucrose. The phase nature of the hydrated amorphate is equivalent to an aqueous solution that is supersaturated with respect to crystalline sucrose. A model was developed for the lag time which accounts for the experimental results. © 1990, Plenum Publishing Corporation. All rights reserved.
引用
收藏
页码：1278 / 1281
页数：4
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