FAMILIAL PLASMA CHOLESTEROL ESTER DEFICIENCY - A STUDY OF ERYTHROCYTES

被引：80
作者：
GJONE, E
TORSVIK, H
NORUM, KR
机构：
[1] Medical Department A and Institute of Clinical Biochemistry, University of Oslo, Rikshospitalet, Oslo
来源：
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 1968年 / 21卷 / 04期
关键词：
Cholesterol; Cholesterol acyltransferase; Enzymes; Erythrocytes; Inborn errors; Lecithin; Lecithins; Lipid metabolism; Phospholipids;
D O I：
10.3109/00365516809077001
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The erythrocytes of three sisters with plasma cholesterol ester deficiency and lack of plasma lecithin: cholesterol acyltransferase (LCAT) have been studied. The erythrocyte content of cholesterol was markedly increased. Their total lipid phosphorus was normal, lecithin being increased and phosphatidylethanolamine and sphingomyelin decreased. The fatty acid composition of the phospholipids was not normal as an increase in linoleic acid and a decrease in arachidonic and very long chain fatty acids were demonstrated. The absence of LCAT in plasma of the patients may explain the major lipid abnormalities of their red cells. © 1968 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码：327 / &
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