EFFECT OF NEONATAL MONOSODIUM GLUTAMATE ON THE ACTIVITIES OF GLUTAMATE-DEHYDROGENASE AND AMINOTRANSFERASES IN THE CIRCUMVENTRICULAR ORGANS OF RAT-BRAIN

被引：5
|
作者：
BAWARI, M
BABU, GN
ALI, MM
MISRA, UK
机构：
[1] SANJAY GANDHI POSTGRAD INST MED SCI,DEPT NEUROL,LUCKNOW 226014,UTTAR PRADESH,INDIA
[2] IND TOXICOL RES CTR,DIV NEUROTOXICOL,LUCKNOW 226001,UTTAR PRADESH,INDIA
来源：
AMINO ACIDS | 1995年 / 8卷 / 04期
关键词：
AMINO ACIDS; MONOSODIUM GLUTAMATE; GLUTAMATE DEHYDROGENASE; AMINOTRANSFERASES;
D O I：
10.1007/BF00806557
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glutamate (Glu) the major amino acid in mammalian brain and most dietary proteins possesses neurotransmitter as well as neurotoxic properties. We administered monosodium glutamate (MSG)4 mg/g bwt, sc on postnatal day (PND) 1 through 10 to rats on alternate days or daily and sacrificed them on PND 45 or PND 90 respectively. The activities of glutamate dehydrogenase and aminotransferases were evaluated in the circumventricular organs of brain. Results show that neonatal MSG produces alterations in glutamate metabolism in blood-brain-barrier deficient regions.
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页码：393 / 395
页数：3
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