ACTIVITY OF SOME MANNICH-BASES OF CONJUGATED STYRYL KETONES AGAINST CANDIDA-ALBICANS

被引：0

作者：

DIMMOCK, JR ^{[1
]}

KUMAR, P ^{[1
]}

MANAVATHU, EK ^{[1
]}

OBEDEANU, N ^{[1
]}

GREWAL, J ^{[1
]}

机构：

[1] WAYNE STATE UNIV,DEPT MED,DETROIT,MI 48202

来源：

PHARMAZIE | 1994年 / 49卷 / 12期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of Mannich bases of conjugated styryl ketones displayed activity against Candida albicans strains 3153A and B311. Antifungal potency was influenced by the relative hydrophobicities of the molecules and on occasions by the electronic nature of the aryl substituents. The compounds inhibited one or more of the following enzymes in the glutathione metabolic pathway namely glutathione S-transferases, glutathione reductase, gamma-glutamyl transpeptidase and glutathione peroxidase. Nearly half of the compounds examined on the yeast-to-mycelium transition in C. albicans 3153A prevented this conversion from occuring.

引用

页码：909 / 912

页数：4

共 16 条

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