TRANSPORT CHARACTERISTICS OF CEFTIBUTEN, CEFIXIME AND CEPHALEXIN ACROSS HUMAN JEJUNAL BRUSH-BORDER MEMBRANE

被引：28
作者：
SUGAWARA, M
ISEKI, K
MIYAZAKI, K
SHIROTO, H
KONDO, Y
UCHINO, JI
机构：
[1] HOKKAIDO UNIV HOSP,SCH MED,DEPT PHARM,KITA 14 JO,NISHI 5 CHOME,KITA KU,SAPPORO 060,JAPAN
[2] HOKKAIDO UNIV HOSP,SCH MED,DEPT SURG 1,KITA KU,SAPPORO 060,JAPAN
来源：
JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 12期
关键词：
D O I：
10.1111/j.2042-7158.1991.tb03203.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The transport characteristics of orally active cephalosporins, ceftibuten, cefixime and cephalexin have been examined using brush border membrane vesicles isolated from human jejunum. In the initial uptake of ceftibuten, the stimulation and overshoot phenomena were observed in the presence of an inward H+ gradient. Effects of H+ gradient on the uptake of cefixime and cephalexin were low and no overshoot was observed. These transport characteristics, especially uphill transport phenomena, were in agreement with previous results obtained from rat intestinal brush-border membrane vesicles and suggest that these beta-lactam antibiotics are absorbed by different transport systems, despite their similar molecular structures.
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页码：882 / 884
页数：3
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