CHRONIC LISURIDE HYDROGEN MALEATE ADMINISTRATION ENHANCES MUSCARINIC RECEPTOR-BINDING IN SENESCENT RAT-BRAIN

被引：1
作者：
HIRATA, H
OGAWA, N
MIZUKAWA, K
HABA, K
ASANUMA, M
MORI, A
OTA, Z
机构：
[1] OKAYAMA UNIV,SCH MED,DEPT INTERNAL MED 3,OKAYAMA 700,JAPAN
[2] OKAYAMA UNIV,SCH MED,DEPT ANAT,OKAYAMA 700,JAPAN
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 1991年 / 19卷 / 04期
关键词：
LISURIDE HYDROGEN MALEATE; PIRENZEPINE; MUSCARINIC RECEPTOR; SENESCENT RAT; RECEPTOR AUTORADIOGRAPHY; ACETYLCHOLINE NEURONAL SYSTEM;
D O I：
10.1177/030006059101900404
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Changes in the regional density of muscarinic-1 (M1) receptors and the effect of lisuride hydrogen maleate on these changes were studied in senescent rat brain by in vitro autoradiography. In young adult controls, M1 receptor binding was most dense in the striatum and hippocampus, followed by the cerebral cortex and amygdala. Binding to M1 receptors was markedly lower in these areas of the senescent brain compared with the young adult brain. These decreases were reversed by intraperitoneal administration of 50-mu-g/kg.day lisuride for 14 days. The present results indicate that the therapeutic efficacy of lisuride depends on normalization of not only monoamine systems but also acetylcholine systems.
引用
收藏
页码：318 / 325
页数：8
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