Evaluation The Toxicity Of Accumulated Dose Of Tramadol On Gonads Of Albino Rat

In this experiment we focus on studying some changes on testicles and ovaries in albino rats, after exposure to high and low doses of Tramadol. Rats were divided into 6 groups (3 male groups and 3 female groups). Group (1) control male group, received (saline), Group (2) and Group (3) received oral doses of tramadol (high dose 90 mg / kg b.w. / day) and (low dose 45 mg / kg b.w. / day)respectively for two months, Group (4) control female group, received (saline), Group (5) and Group (6) received oral doses of tramadol (high dose 90 mg / kg b.w. / day) and (low dose 45 mg / kg b.w. / day)respectively for two months, harmonal and histopathological examination were carried out. significant decreases in sperm count of high dose, low dose groups. Testesteron, LH and FSH hormones exhibited significant decrease in its level of groups (2&3) when compared with control group at P<0.05. Revealed significant decrease in level of LH and FSH hormones of the female rats (groups5&6) when compared with female control group at P<0.05. Progesterone hormone revealed a significant increase in low dose when compared with control female. tramadol has a toxic effect on on a gonand functions, these findings may provide a possible explanation for delayed fertility and psychological changes associated with tramadol abuse.