MICROSCOPIC THYMOMA - HISTOLOGICAL EVIDENCE OF MULTIFOCAL CORTICAL AND MEDULLARY ORIGIN

被引：20

作者：

PESCARMONA, E ^{[1
]}

ROSATI, S ^{[1
]}

PISACANE, A ^{[1
]}

RENDINA, EA ^{[1
]}

VENUTA, F ^{[1
]}

BARONI, CD ^{[1
]}

机构：

[1] UNIV ROME,CATTEDRA CHIRURG TORAC,I-00161 ROME,ITALY

来源：

HISTOPATHOLOGY | 1992年 / 20卷 / 03期

关键词：

THYMUS; THYMOMA; MICROSCOPIC THYMOMA; MYASTHENIA GRAVIS;

D O I：

10.1111/j.1365-2559.1992.tb00966.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Twenty cases of macroscopically non-neoplastic thymuses obtained from patients with myasthenia gravis have been studied histologically. Seven cases were characterized by lymphoid follicular hyperplasia and 13 by involutional changes of variable degree. In three cases (15%), one with lymphoid follicular hyperplasia and two with involutional changes, multiple microscopic epithelial lesions, 0.2-0.4 mm in diameter and consistent with foci of microscopic thymoma, were observed. Most of them were related to the thymic cortex and one, displaying a different histological pattern, was located in a medullary area. These observations provide morphological evidence of a possible multifocal origin of thymoma from distinct epithelial clones present in the different topographic areas of the human thymus.

引用

页码：263 / 266

页数：4

共 8 条

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