ANTI-MYCOBACTERIAL DRUGS THAT INHIBIT MYCOLIC ACID SYNTHESIS

被引：10
作者：
TAKAYAMA, K [1 ]
DAVIDSON, LA [1 ]
机构：
[1] UNIV WISCONSIN, INST ENZYME RES, MADISON, WI 53706 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1979年 / 4卷 / 12期
关键词：
D O I：
10.1016/0968-0004(79)90301-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Antimycobacterial drugs such as isoniazid; ethionamide and thiocarlide are inhibitors of mycolic acid synthesis in Mycobacterium tuberculosis. Isoniazid in particular appears to block the formation of a Δ5-C24:1 fatty acid which could be a precursor of mycolic acids. © 1979.
引用
收藏
页码：280 / 282
页数：3
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