THE ROLE OF THE MACULA DENSA IN RENIN SYNTHESIS

被引：6
作者：
MORGAN, T [1 ]
BARRETT, G [1 ]
ZHANG, YL [1 ]
ALCORN, D [1 ]
机构：
[1] UNIV MELBOURNE,DEPT ANAT,PARKVILLE,VIC 3052,AUSTRALIA
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1991年 / 18卷 / 02期
关键词：
ACE INHIBITION; ANGIOTENSIN-II; BETA-BLOCKADE; HYDRONEPHROSIS; MESSENGER RNA; RENIN; SODIUM DEPLETION;
D O I：
10.1111/j.1440-1681.1991.tb01421.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The role of the macula densa in renin synthesis was studied using mice with one hydronephrotic kidney. 2. Renin synthesis was assessed by measurement of renal renin, renal mRNA for renin and plasma renin. 3. Sodium depletion stimulated mRNA and renal renin to a similar extent in the hydronephrotic and contralateral kidney. 4. Enalapril stimulated mRNA concentration in both kidneys but renal renin did not rise in the hydronephrotic kidney. 5. Propanolol did not alter the response to sodium depletion in either kidney. 6. The macula densa is not crucial for the stimulation of renin synthesis following sodium depletion. However, it may regulate renin production after mRNA synthesis, possibly by controlling the conversion of prorenin to renin.
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页码：123 / 126
页数：4
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