TRANSFORMING GROWTH-FACTOR-BETA - ROLE IN MEDIATING SERUM-INDUCED ENDOTHELIN PRODUCTION BY VASCULAR ENDOTHELIAL-CELLS

被引：40
作者：
BROWN, MR
VAUGHAN, J
JIMENEZ, LL
VALE, W
BAIRD, A
机构：
[1] UNIV CALIF SAN DIEGO,DEPT SURG,LA JOLLA,CA 92093
[2] SALK INST BIOL STUDIES,CLAYTON FDN LABS PEPTIDE BIOL,LA JOLLA,CA 92037
[3] SCRIPPS CLIN & HOSP,WHITTIER INST,LA JOLLA,CA 92037
来源：
ENDOCRINOLOGY | 1991年 / 129卷 / 05期
关键词：
D O I：
10.1210/endo-129-5-2355
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Studies were performed to characterize the identity of the factors present in calf serum that stimulate endothelin (ET) production by vascular endothelial cells in culture. Two putative candidates responsible for the ET-releasing activity present in serum are members of the transforming growth factor-beta (TGF-beta) superfamily, TGF-beta-1 and activin A. TGF-beta-1 antiserum was used to block the actions of TGF-beta-1, and follistatin was used to block the actions of activin. Treatment of serum with TGF-beta-1 antiserum attenuates ET production by vascular endothelial cells. TGF-beta-1 antiserum (1-mu-l) completely prevents the release of ET produced on by 0.1% and 0.3% serum. Follistatin is a potent inhibitor of activin-induced ET release but does not alter serum-induced ET production. Because serum-induced ET release is dependent on TGF-beta, it may be a physiological regulator of ET production by vascular endothelial cells.
引用
收藏
页码：2355 / 2360
页数：6
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