5-FLUOROURACIL NEUROTOXICITY

被引：28
作者：
MOORE, DH
FOWLER, WC
CRUMPLER, LS
机构：
[1] Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill
来源：
GYNECOLOGIC ONCOLOGY | 1990年 / 36卷 / 01期
关键词：
D O I：
10.1016/0090-8258(90)90127-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Two cases of 5-fluorouracil-induced neurotoxicity from the University of North Carolina are presented. 5-Fluorouracil metabolism is briefly discussed with reference to possible mechanisms for the neurotoxicity. A possible role for thiamine supplementation in the prevention of this unusual complication is supported by our experience. © 1990.
引用
收藏
页码：152 / 154
页数：3
相关论文
共 30 条
[1]   THIAMIN STATUS OF PATIENTS TREATED WITH DRUG-COMBINATIONS CONTAINING 5-FLUOROURACIL [J].
AKSOY, M ;
BASU, TK ;
BRIENT, J ;
DICKERSON, JWT .
EUROPEAN JOURNAL OF CANCER, 1980, 16 (08) :1041-1045
[2]  
BAGSHAW MA, 1961, AMER J ROENTGENOL RA, V85, P822
[3]  
BASU TK, 1974, INT J VITAM NUTR RES, V44, P53
[4]  
BOILEAU G, 1971, CANCER CHEMOTH REP 1, V55, P595
[5]  
BOSCH L, 1958, CANCER RES, V18, P335
[6]  
CAMPBELL TN, 1982, CANCER TREAT REP, V66, P1723
[7]  
CHENG E, 1980, P AM ASSOC CANC RES, V21, P350
[8]   THYMIDYLATE SYNTHETASE - TARGET ENZYME IN CANCER CHEMOTHERAPY [J].
DANENBERG, PV .
BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 473 (02) :73-92
[9]  
DEVITA VT, 1976, CANCER-AM CANCER SOC, V38, P509, DOI 10.1002/1097-0142(197607)38:1<509::AID-CNCR2820380175>3.0.CO
[10]  
2-A
123