Pregnancy and Vascular Liver Disease

被引：31

作者：

Bissonnette, Julien ^{[1
]}

Durand, Francois ^{[1
,2
]}

de Raucourt, Emmanuelle ^{[3
]}

Ceccaldi, Pierre-Francois ^{[4
]}

Plessier, Aurelie ^{[1
,2
]}

Valla, Dominique ^{[1
,2
]}

Rautou, Pierre-Emmanuel ^{[1
,2
,5
,6
]}

机构：

[1] Hop Beaujon, Assistance Publ Hop Paris, Serv Hepatol, 100 Blvd Gen Leclerc, F-92100 Clichy, France

[2] Univ Paris Diderot Paris 7, Hop Bichat, INSERM, Ctr Rech Biomed Bichat Beaujon CRB3,U773, Paris, France

[3] Hop Beaujon, Assistance Publ Hop Paris, Lab Hematol Biol, Clichy, France

[4] Hop Beaujon, Assistance Publ Hop Paris, Serv Obstet Gyneecol, Clichy, France

[5] INSERM, Paris Cardiovasc Res Ctr PARCC, U970, Paris, France

[6] Univ Paris 05, UMR S970, Paris, France

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY | 2015年 / 5卷 / 01期

关键词：

pregnancy; Budd-Chiari syndrome; portal vein thrombosis; non-cirrhotic portal hypertension;

D O I：

10.1016/j.jceh.2014.12.007

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Vascular disorders of the liver frequently affect women of childbearing age. Pregnancy and the postpartum are prothrombotic states. Pregnancy seems to be a trigger for Budd-Chiari syndrome in patients with an underlying prothrombotic disorder. Whether pregnancy is a risk factor for other vascular liver disorders is unknown. In women with a known vascular liver disorder and a desire for pregnancy, stabilisation of the liver disease, including the use of a portal decompressive procedure when indicated, should be reached prior to conception. The presence of esophageal varices should be screened and adequate prophylaxis of bleeding applied in a manner similar to what is recommended for patients with cirrhosis. Most women likely benefit from anticoagulation during pregnancy and the postpartum. Labor and delivery are best managed by a multidisciplinary team with experience in this situation. Assisted vaginal delivery is the preferred mode of delivery. Although the risk of miscarriage and premature birth is heightened, current management of these diseases makes it very likely to see the birth of a live baby when pregnancy reaches 20 weeks of gestation.

引用

页码：41 / 50

页数：10

共 95 条

[1] Non-cirrhotic portal hypertension in pregnancy [J].