PHARMACOLOGICAL STUDIES OF ALLERGIC COUGH IN THE GUINEA-PIG

The pharmacological mechanisms of allergic cough in the guinea pig were studied. Actively sensitized guinea pigs were exposed to aerosols of antigen to elicit coughing. In separate experiments, naive guinea pigs were exposed to aerosols of capsaicin to elicit coughing. Both allergic and capsaicin-induced cough were inhibited by loratadine (0.3-10 mg kg(-1) p.o.) and chlorpheniramine (0.1-3.0 mg kg(-1) p.o.). Neither cimetidine (10 mg kg(-1) s.c.), nor thioperamide (3-10 mg kg(-1) s.c.), inhibited allergic or capsaicin-induced cough. Codeine (3-30 mg kg(-1) p.o.), salbutamol (0.003-3.0 mg kg(-1) s.c.) and ipratropium (0.03-1.0 mg kg(-1) s.c.) inhibited both allergic and capsaicin-induced cough. Hexamethonium (10 and 30 mg kg(-1) s.c.) inhibited allergic, but not capsaicin-induced cough. Allergic and capsaicin-induced cough were unaffected by phenidone (5.0 and 10.0 mg kg(-1) s.c.). Indomethacin (5.0 and 10.0 mg kg(-1) s.c.) had no effect on allergic cough but slightly inhibited capsaicin-induced cough. We conclude that allergic and capsaicin-induced cough are modulated by histamine H-1 receptor and cholinergic mechanisms. Histamine H-2 or histamine H-3 receptor mechanisms, and lipoxygenase and cyclooxygenase products of arachidonic acid metabolism do not influence allergic and capsaicin-induced cough. Ganglionic mechanisms play a minor role in the production of allergic cough and no role in capsaicin-induced cough.