COMPARISON OF MORTALITY IN PATIENTS TREATED WITH PROPAFENONE TO THOSE TREATED WITH A VARIETY OF ANTIARRHYTHMIC DRUGS FOR SUPRAVENTRICULAR ARRHYTHMIAS

被引：16
作者：
PRITCHETT, ELC
WILKINSON, WE
CLAIR, WK
MCCARTHY, EA
机构：
[1] DUKE UNIV,DUKE S HOSP,MED CTR,DEPT COMMUNITY & FAMILY MED,DURHAM,NC 27710
[2] DUKE UNIV,DUKE S HOSP,MED CTR,DEPT MED,DIV CLIN PHARMACOL,DURHAM,NC 27710
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 1993年 / 72卷 / 01期
关键词：
D O I：
10.1016/0002-9149(93)90231-Z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Antiarrhythmic drugs are often prescribed to treat patients with supraventricular arrhythmias, and recent placebo-controlled clinical trials demonstrated the efficacy of these compounds in reducing recurrences of symptomatic arrhythmias.1-4 However, other recent studies suggested that some antiarrhythmic drugs may increase mortality in some groups of patients.5-7 Thus, the safety of antiarrhythmic drugs remains uncertain. We previously examined this problem by comparing mortality in various data bases of patients receiving antiar-rhythmic drugs.8 The present study compared mortality in 2 data bases of patients with supraventricular arrhythmias to examine whether we could observe any excess mortality in patients treated with propafenone hydrochloride (referred to later as propafenone) for supraventricular arrhythmias. © 1993.
引用
收藏
页码：108 / 110
页数：3
相关论文
共 9 条
[1]   PREVENTION OF SYMPTOMATIC RECURRENCES OF PAROXYSMAL ATRIAL-FIBRILLATION IN PATIENTS INITIALLY TOLERATING ANTIARRHYTHMIC THERAPY - A MULTICENTER, DOUBLE-BLIND, CROSSOVER STUDY OF FLECAINIDE AND PLACEBO WITH TRANSTELEPHONIC MONITORING [J].
ANDERSON, JL ;
GILBERT, EM ;
ALPERT, BL ;
HENTHORN, RW ;
WALDO, AL ;
BHANDARI, AK ;
HAWKINSON, RW ;
PRITCHETT, ELC .
CIRCULATION, 1989, 80 (06) :1557-1570
[2]   USEFULNESS OF PROPAFENONE FOR RECURRENT PAROXYSMAL ATRIAL-FIBRILLATION [J].
CONNOLLY, SJ ;
HOFFERT, DL .
AMERICAN JOURNAL OF CARDIOLOGY, 1989, 63 (12) :817-819
[3]   EFFICACY AND SAFETY OF QUINIDINE THERAPY FOR MAINTENANCE OF SINUS RHYTHM AFTER CARDIOVERSION - A METAANALYSIS OF RANDOMIZED CONTROL TRIALS [J].
COPLEN, SE ;
ANTMAN, EM ;
BERLIN, JA ;
HEWITT, P ;
CHALMERS, TC .
CIRCULATION, 1990, 82 (04) :1106-1116
[4]   MORTALITY AND MORBIDITY IN PATIENTS RECEIVING ENCAINIDE, FLECAINIDE, OR PLACEBO - THE CARDIAC-ARRHYTHMIA SUPPRESSION TRIAL [J].
ECHT, DS ;
LIEBSON, PR ;
MITCHELL, LB ;
PETERS, RW ;
OBIASMANNO, D ;
BARKER, AH ;
ARENSBERG, D ;
BAKER, A ;
FRIEDMAN, L ;
GREENE, HL ;
HUTHER, ML ;
RICHARDSON, DW .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (12) :781-788
[5]   ANTIARRHYTHMIC DRUG-THERAPY AND CARDIAC MORTALITY IN ATRIAL-FIBRILLATION [J].
FLAKER, GC ;
BLACKSHEAR, JL ;
MCBRIDE, R ;
KRONMAL, RA ;
HALPERIN, JL ;
HART, RG .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1992, 20 (03) :527-532
[6]   FLECAINIDE ACETATE PREVENTS RECURRENCE OF SYMPTOMATIC PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA [J].
HENTHORN, RW ;
WALDO, AL ;
ANDERSON, JL ;
GILBERT, EM ;
ALPERT, BL ;
BHANDARI, AK ;
HAWKINSON, RW ;
PRITCHETT, ELC .
CIRCULATION, 1991, 83 (01) :119-125
[7]  
KALBFLEISCH JD, 1980, STATISTICAL ANAL FAI
[8]   MORTALITY IN PATIENTS TREATED WITH FLECAINIDE AND ENCAINIDE FOR SUPRAVENTRICULAR ARRHYTHMIAS [J].
PRITCHETT, ELC ;
WILKINSON, WE .
AMERICAN JOURNAL OF CARDIOLOGY, 1991, 67 (11) :976-980
[9]   PROPAFENONE TREATMENT OF SYMPTOMATIC PAROXYSMAL SUPRAVENTRICULAR ARRHYTHMIAS - A RANDOMIZED, PLACEBO-CONTROLLED, CROSSOVER TRIAL IN PATIENTS TOLERATING ORAL-THERAPY [J].
PRITCHETT, ELC ;
MCCARTHY, EA ;
WILKINSON, WE .
ANNALS OF INTERNAL MEDICINE, 1991, 114 (07) :539-544
1