共 69 条
PHARMACOLOGY OF VIGABATRIN
被引:51
作者:

SABERS, A
论文数: 0 引用数: 0
h-index: 0
机构: University Clinic of Neurology, Hvidovre Hospital, Hvidovre

GRAM, L
论文数: 0 引用数: 0
h-index: 0
机构: University Clinic of Neurology, Hvidovre Hospital, Hvidovre
机构:
[1] University Clinic of Neurology, Hvidovre Hospital, Hvidovre
来源:
PHARMACOLOGY & TOXICOLOGY
|
1992年
/
70卷
/
04期
关键词:
D O I:
10.1111/j.1600-0773.1992.tb00465.x
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Vigabatrin (gamma-vinyl GABA) is a relatively new antiepileptic drug. Vigabatrin increases the concentration of gamma-aminobutyric acid (GABA) in the brain by inhibiting the major GABA metabolizing enzyme, GABA transaminase, Controlled clinical trials have demonstrated an excellent antiepileptic effect of vigabatrin, especially in the treatment of partial epilepsies. Long-term evaluations have shown no signs of tolerance development. Vigabatrin decreases the plasma concentration of phenytoin during concomitant therapy, the only drug with which an interaction seems to occur. In general, vigabatrin is well tolerated. Psychotic reactions occur in 3-6% of patients. Other frequent side effects are sedation and weight increase. Chronic vigabatrin intoxication in animals caused development of intramyelinic oedema, appearing as microvacuoles in brain white matter. No microvacuolation has been observed in humans, even after long-term treatment. Vigabatrin seems a very valuable new antiepileptic drug.
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页码:237 / 243
页数:7
相关论文
共 69 条
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YASARGIL, G
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HOSP ZURICH,DEPT NEUROL,FRAUENKLIN STR 26,CH-8091 ZURICH,SWITZERLAND

EGLI, M
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HOSP ZURICH,DEPT NEUROL,FRAUENKLIN STR 26,CH-8091 ZURICH,SWITZERLAND

WIESER, HG
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h-index: 0
机构: UNIV HOSP ZURICH,DEPT NEUROL,FRAUENKLIN STR 26,CH-8091 ZURICH,SWITZERLAND

WIESTLER, OD
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HOSP ZURICH,DEPT NEUROL,FRAUENKLIN STR 26,CH-8091 ZURICH,SWITZERLAND
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SCHROEDER, CE
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LITWAK, MS
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机构: YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROL,BRONX,NY 10461

STEWARD, DL
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机构:
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MUMFORD, J
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MERRELL DOW RES INST,WINNERSH,BERKS,ENGLAND MERRELL DOW RES INST,WINNERSH,BERKS,ENGLAND
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HUOT, S
论文数: 0 引用数: 0
h-index: 0
机构:
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论文数: 0 引用数: 0
h-index: 0
机构: BOSTON UNIV, SCH MED, DEPT NEUROL, BOSTON, MA 02118 USA

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论文数: 0 引用数: 0
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机构: BOSTON UNIV, SCH MED, DEPT NEUROL, BOSTON, MA 02118 USA

SMITH, DB
论文数: 0 引用数: 0
h-index: 0
机构: BOSTON UNIV, SCH MED, DEPT NEUROL, BOSTON, MA 02118 USA

TREIMAN, DM
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h-index: 0
机构: BOSTON UNIV, SCH MED, DEPT NEUROL, BOSTON, MA 02118 USA

WILDER, BJ
论文数: 0 引用数: 0
h-index: 0
机构: BOSTON UNIV, SCH MED, DEPT NEUROL, BOSTON, MA 02118 USA

BENMENACHEM, E
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h-index: 0
机构: BOSTON UNIV, SCH MED, DEPT NEUROL, BOSTON, MA 02118 USA

NAPOLIELLO, MJ
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h-index: 0
机构: BOSTON UNIV, SCH MED, DEPT NEUROL, BOSTON, MA 02118 USA

SHERRY, KM
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h-index: 0
机构: BOSTON UNIV, SCH MED, DEPT NEUROL, BOSTON, MA 02118 USA

SZABO, GK
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机构: BOSTON UNIV, SCH MED, DEPT NEUROL, BOSTON, MA 02118 USA
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DULAC, O
论文数: 0 引用数: 0
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机构: WINNERSH RES CTR,MERRELL DOW RES INST,WINNERSH RG11 5HQ,BERKS,ENGLAND

LUNA, D
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机构: WINNERSH RES CTR,MERRELL DOW RES INST,WINNERSH RG11 5HQ,BERKS,ENGLAND

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h-index: 0
机构: WINNERSH RES CTR,MERRELL DOW RES INST,WINNERSH RG11 5HQ,BERKS,ENGLAND

MONDRAGON, S
论文数: 0 引用数: 0
h-index: 0
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BEAUMONT, D
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h-index: 0
机构: WINNERSH RES CTR,MERRELL DOW RES INST,WINNERSH RG11 5HQ,BERKS,ENGLAND

MUMFORD, JP
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COCITO, L
论文数: 0 引用数: 0
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机构:
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MAFFINI, M
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV GENOA,NEUROL CLIN,VIA A DE TONI 5,I-16132 GENOA,ITALY UNIV GENOA,NEUROL CLIN,VIA A DE TONI 5,I-16132 GENOA,ITALY

PERFUMO, P
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV GENOA,NEUROL CLIN,VIA A DE TONI 5,I-16132 GENOA,ITALY UNIV GENOA,NEUROL CLIN,VIA A DE TONI 5,I-16132 GENOA,ITALY

RONCALLO, F
论文数: 0 引用数: 0
h-index: 0
机构:
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LOEB, C
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV GENOA,NEUROL CLIN,VIA A DE TONI 5,I-16132 GENOA,ITALY UNIV GENOA,NEUROL CLIN,VIA A DE TONI 5,I-16132 GENOA,ITALY