Consequences of Obstructive Sleep Apnea Cardiovascular Risk of Obstructive Sleep Apnea and Whether Continuous Positive Airway Pressure Reduces that Risk

被引：33
作者：
Khayat, Rami [1 ]
Pleister, Adam [2 ,3 ]
机构：
[1] Ohio State Univ, Wexner Med Ctr, Internal Med Pulm Allergy Crit Care & Sleep Med, Suite 200,473 West 12th Ave, Columbus, OH 43210 USA
[2] Ohio State Univ, Div Cardiovasc Med Adv Heart Failure & Cardiac Tr, Davis Heart & Lung Res Inst, Dept Internal Med,Wexner Med Ctr, Suite 200,473 West 12th Ave, Columbus, OH 43210 USA
[3] Ohio State Univ, Div Pulm Allergy Crit Care & Sleep Med Sleep Med, Davis Heart & Lung Res Inst, Dept Internal Med,Wexner Med Ctr, Suite 200,473 West 12th Ave, Columbus, OH 43210 USA
来源：
SLEEP MEDICINE CLINICS | 2016年 / 11卷 / 03期
关键词：
Obstructive sleep apnea; Sleep-disordered breathing; Cardiovascular disease; Systemic hypertension; Intermittent hypoxia; Sympathetic activation; Coronary artery disease; Heart failure;
D O I：
10.1016/j.jsmc.2016.05.002
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Obstructive sleep apnea (OSA) is present in up to 25% of otherwise healthy individuals. OSA is associated with intermittent hypoxia, oxidative stress, sympathetic activation, and an inflammatory response. These perturbations mediate the role of OSA as an independent and modifiable risk factor for cardiovascular disease (CVD). OSA can induce CVD or accelerate the progression of CVD into an end-stage disorder, including heart failure and stroke. Current clinical recommendations are based on existing clinical trial data and the clinical experience of our program; current and future clinical trials will help to optimize management of OSA in the setting of CVD.
引用
收藏
页码：273 / +
页数：15
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