FACTORS INFLUENCING OXYGEN CONCENTRATION GRADIENTS IN THE INTERVERTEBRAL-DISK - A THEORETICAL-ANALYSIS

被引：95

作者：

STAIRMAND, JW ^{[1
]}

HOLM, S ^{[1
]}

URBAN, JPG ^{[1
]}

机构：

[1] UKAEA,SPRINGFIELDS LAB,PRESTON,LANCS,ENGLAND

来源：

SPINE | 1991年 / 16卷 / 04期

关键词：

Cell density; Intervertebral disc; Nutrition; Oxygen; Vertebral end-plate;

D O I：

10.1097/00007632-199104000-00010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Oxygen concentration gradients in the intervertebral disc were calculated to examine the effects of exchange area and disc thickness on oxygen concentrations and oxygen flux into the disc. The concentration gradients were determined using the two-dimensional Poisson equation with experimental values for oxygen consumption rate and oxygen diffusion. The calculated gradients were steep, and the oxygen concentrations in the center of thick discs were low, in agreement with experimental gradients. The results support the hypothesis that maximum cell density in the disc is determined by nutrient supply and that exchange area and disc thickness are critical parameters.

引用

页码：444 / 449

页数：6

共 21 条

[1]

Buerk D.G., Saidel G.M., Local kinetics of oxygen metabolism in brain and liver tissues, Microvascres, 13, pp. 345-353, (1977)

[2]

Crock H.W., Goldwasser M., Anatomic studies of the circulation in the region of the vertebral endplate in adult greyhound dogs, Spine, 9, pp. 702-706, (1984)

[3]

Freyer J.P., Sutherland R.M., Regulation of growth saturation and development of necrosis in EMT6/Ro multicellular spheroids by the glucose and oxygen supply, Cancer Res, 46, pp. 3504-3512, (1986)

[4]

Holm S., Maraudas A., Urban J., Selstam G., Nachemson A., Nutrition of the intervertebral disc, Connect Tissue Res, 8, pp. 101-119, (1981)

[5]

Holm S., Nachemson A., Cellularity in the Lumbar Intervertebral Disc and Its Relevance to Nutrition, Issls Trans, (1983)

[6]

Holm S., Selstam G., Nachemson A., Carbohydrate metabolism and concentration profiles of solutes in the canine lumbar intervertebral disc, Acta Physiol Scand, 115, pp. 147-156, (1982)

[7]

Katz M., Hargens A.R., Garfm S.R., Intervertebral disc nutrition: Diffusion versus convection, Clin Orthop, 210, pp. 243-245, (1986)

[8]

Marcus R.F., The effect of low oxygen concentrations on growth, glycolysis and sulfate incorporation by articular chondrocytes in monolayer culture, Arthritis Rheum, 16, pp. 646-656, (1973)

[9]

Maraudas A., Stockwell R.A., Nachemson A., Urban J., Factors involved in the nutrition of human lumbar intervertebral disc: Cellularity and diffusion of glucose in vitro, J Anat, 120, pp. 113-130, (1975)

[10]

Massaro T.A., Fatt I., Oxygen diffusion in large single-celled organisms, Bull Math Biol, 31, pp. 327-340, (1969)

← 1 2 3 →