R-VERAPAMIL DECREASES ANTIESTROGEN RESISTANCE IN A BREAST-CANCER MODEL

被引：0

作者：

KELLEN, JA ^{[1
]}

WONG, A ^{[1
]}

GEORGES, E ^{[1
]}

LING, V ^{[1
]}

机构：

[1] ONTARIO CANC INST,TORONTO M4X 1K9,ONTARIO,CANADA

来源：

ANTICANCER RESEARCH | 1991年 / 11卷 / 02期

关键词：

BREAST CANCER; TAMOXIFEN (ANTIESTROGEN); DRUG RESISTANCE; CALCIUM CHANNEL BLOCKERS; R-VERAPAMIL; P-GLYCOPROTEIN;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Drug resistance eventually limits the effectiveness of antiestrogens in breast cancer treatment. Pharmacological reversal of this refractoriness has been attempted with R-Verapamil, a well tolerated calcium channel blocker. This drug significantly decreased the incidence of lung foci after intravenous seeding of the R3230AC rat adenocarcinoma; this effect was correlated with reduction in the expression of P-glycoprotein. The simultanous administration of antiestrogens with a non-toxic enantiomer of Verapamil was beneficial in the tumour model investigated.

引用

页码：809 / 812

页数：4

共 13 条

[1] MULTIDRUG RESISTANCE AND ITS CIRCUMVENTION [J].