IDENTIFICATION OF A COMPETITIVE HGF ANTAGONIST ENCODED BY AN ALTERNATIVE TRANSCRIPT

被引：209

作者：

CHAN, AML ^{[1
]}

RUBIN, JS ^{[1
]}

BOTTARO, DP ^{[1
]}

HIRSCHFIELD, DW ^{[1
]}

CHEDID, M ^{[1
]}

AARONSON, SA ^{[1
]}

机构：

[1] NCI,CELLULAR & MOLEC BIOL LAB,BETHESDA,MD 20892

来源：

SCIENCE | 1991年 / 254卷 / 5036期

关键词：

D O I：

10.1126/science.1720571

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We identified a naturally occurring hepatocyte growth factor (HGF) variant, whose predicted sequence extends only through the second kringle domain of this plasminogen-related molecule. This smaller molecule, derived from an alternative HGF transcript, lacked mitogenic activity but specifically inhibited HGF-induced mitogenesis. Cross-linking studies demonstrated that the truncated molecule competes with HGF for binding to the HGF receptor, which has been identified as the c-met proto-oncogene product. Thus, the same gene encodes both a growth factor and its direct antagonist.

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页码：1382 / 1385

页数：4

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