ALPHA-1,4-GLUCOSIDASE ACTIVITY AND THE PRESENCE OF GERMINAL EPITHELIUM-CELLS IN THE SEMEN FOR DIFFERENTIAL-DIAGNOSIS OF OBSTRUCTIVE AND NONOBSTRUCTIVE AZOOSPERMIA

被引：7

作者：

SANDOVAL, L ^{[1
]}

DIAZ, M ^{[1
]}

RIVAS, F ^{[1
]}

机构：

[1] HOSP GINECOOBSTET,IMSS,CMNO,SERV ANDROL,GUADALAJARA 44310,JALISCO,MEXICO

来源：

ARCHIVES OF ANDROLOGY | 1995年 / 35卷 / 02期

关键词：

ALPHA-GLUCOSIDASE; AZOOSPERMIC; DIAGNOSIS; MALE INFERTILITY; MEIOSIS; SEMEN ANALYSIS;

D O I：

10.3109/01485019508987867

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Among azoospermics, the activity of seminal alpha-glucosidase (alpha G) is low in obstruction (OBS) cases, but there is no agreement regarding its value in others. With the hypothesis that a more marked decrease in alpha G activity occurs in OBS than in spermatogenesis arrest (SA), the enzyme was measured in the following groups: (1) vasectomized males (n = 15), (2) azoospermics with OBS (n = 7), (3) azoospermics with SA (n = 11), and (4) fertile males (n = 15). Patients within groups 2 and 3 had a testicular volume greater than or equal to 15 mL, no clinical evidence of abnormal epididymis, normal serum gonadotropins, and histological diagnosis. alpha G activities (mU/g protein, means +/- SD) by group were (1) 131 +/- 60, (2) 312 +/- 186, (3) 728 +/- 303, and (4) 1176 +/- 374. All between-group differences were significant (t test, p < .01), except for groups 1 vs. 2 comparison (.05 > p > .01). These results support the notion that SA is associated with a decrease in alpha G that is less marked than that seen in OBS. The search for germinal epithelium cells in semen also allows discrimination between these two azoospermic groups.

引用

页码：155 / 158

页数：4

共 24 条

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