THE VALUE OF CSF ANALYSIS FOR THE DIFFERENTIAL-DIAGNOSIS OF HTLV-I-ASSOCIATED MYELOPATHY AND MULTIPLE-SCLEROSIS

被引：16
作者：
PUCCIONISOHLER, M
KITZE, B
FELGENHAUER, K
GRAEF, IT
LANGE, P
NOVIS, S
REIBER, H
VAZ, B
机构：
[1] UNIV GOTTINGEN,NEUROL KLIN & POLIKLIN,NEUROCHEM LAB,GOTTINGEN,GERMANY
[2] FED UNIV RIO DE JANEIRO,HUCFF,SERV NEUROL,BR-21945 RIO JANEIRO,BRAZIL
来源：
ARQUIVOS DE NEURO-PSIQUIATRIA | 1995年 / 53卷 / 04期
关键词：
HTLV-I; HAM/TSP; CEREBROSPINAL FLUID; ANTIBODY INDEX;
D O I：
10.1590/S0004-282X1995000500008
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cerebrospinal fluid (CSF) and serum of 17 patients with HAM/TSP (HTLV-I associated myelopathy/tropical spastic paraparesis), six with multiple sclerosis and six with idiopathic epilepsy (non inflammatory control) from Brazil were analysed for the presence of intrathecal synthesis of virus-specific antibodies against measles, rubella, varicella tester virus and herpes simplex virus by enzyme-linked immunosorbent assay (ELISA). All HAM/TSP and multiple sclerosis cases had an intrathecal immune response (oligoclonal IgG). In HAM/TSP, only 1/17 case showed a polyspecific intrathecal immune response against measles and rubella virus. In multiple sclerosis, specific antibodies against measles and rubella (MRZ response) were observed in all patients but not in the control with idiopathic epilepsy. The diagnostic and theoretical relevance of mono- and polyspecific immune responses is discussed for these chronic neurological diseases.
引用
收藏
页码：760 / 765
页数：6
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