PERIPHERAL-TYPE BENZODIAZEPINE RECEPTORS IN HUMAN PROSTATE

被引：5

作者：

ESCUBEDO, E ^{[1
]}

CAMINS, A ^{[1
]}

TRESSERRA, F ^{[1
]}

ADZET, T ^{[1
]}

CAMARASA, J ^{[1
]}

机构：

[1] MUTUA TERRASSA,DEPT PATHOL,BARCELONA,SPAIN

来源：

PHARMACOLOGY | 1993年 / 46卷 / 02期

关键词：

RO; 5-4864; PK-11195; PERIPHERAL BENZODIAZEPINE RECEPTORS; BINDING; HUMAN PROSTATE; PROSTATIC HYPERPLASIA;

D O I：

10.1159/000139036

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Peripheral benzodiazepine receptors have been evidenced in human normal prostate and prostatic nodular hyperplasia using [H-3]Ro 5-4864 and [H-3]PK 11195. Binding of both radioligands was found to be saturable. In normal and pathologic tissues, Scatchard analysis revealed a single population of binding sites. K(D) values of [H-3]PK 11195 in normal and hyperplastic prostates were 14.6 +/- 5.6 and 12 +/- 2.42 nmol/l with B(max) of 12,155 +/- 1,328 and 13,924 +/- 2,454 fmol/mg protein, respectively. Using [H-3]Ro 5-4864, the value of B(max) was similar (13,630 +/- 1,878 fmol/mg protein), but its affinity was 15 times lower when compared to [H-3]PK 11195. Human prostatic nodular hyperplasia is not associated with a change in the density of peripheral benzodiazepine receptors.

引用

页码：115 / 120

页数：6

共 26 条

[1] BINDING OF [H-3] RO 5-4864 AND [H-3] PK 11195 TO CEREBRAL-CORTEX AND PERIPHERAL-TISSUES OF VARIOUS SPECIES - SPECIES-DIFFERENCES AND HETEROGENEITY IN PERIPHERAL BENZODIAZEPINE BINDING-SITES [J].