The potential anticancer activity of extracts derived from the roots of Scutellaria baicalensis on human oral squamous cell carcinoma cells

被引：21

作者：

Sato, Daisuke ^{[1
]}

Kondo, Seiji ^{[1
]}

Yazawa, Kazunaga ^{[2
]}

Mukudai, Yoshiki ^{[1
]}

Li, Chunnan ^{[1
]}

Kamatani, Takaaki ^{[1
]}

Katsuta, Hideyuki ^{[1
]}

Yoshihama, Yasuto ^{[1
]}

Shirota, Tatsuo ^{[1
]}

Shintani, Satoru ^{[1
]}

机构：

[1] Showa Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Ota Ku, 2-1-1 Kitasenzoku, Tokyo 1458515, Japan

[2] Tokyo Univ Marine Sci & Technol, Grad Sch Marine Sci & Technol, Lab Nutraceut & Funct Foods Sci, Minato Ku, Tokyo 1088477, Japan

来源：

MOLECULAR AND CLINICAL ONCOLOGY | 2013年 / 1卷 / 01期

基金：

日本学术振兴会;

关键词：

herbal product; anticancer therapeutic agents; human oral squamous cell carcinoma; angiogenesis;

D O I：

10.3892/mco.2012.14

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Various herb products derived from plants have potent biological effects including anticancer activity. In the present study, the antitumor activity of a herbal product derived from the Scutellaria baicalensis (S. baicalensis) was examined, using in vitro assays in a human oral squamous cell carcinoma (OSCC) cell line. Results showed that S. baicalensis root extract at the concentration of 100 mu g/ml inhibited monolayer- and anchorage-independent growth in human OSCC cell lines, while not affecting the adhering abilities of cells. This suggested that it did not alter the expression of any of the adhesion receptors that mediate cell-extracellular matrix (ECM) interactions. The S. baicalensis root extract demonstrated potent cytostatic and apoptotic effects due to the downregulation of the cyclin-dependent kinase 4 expression and its partner cyclin D1, resulting in G1 arrest and poly (ADP-ribose) polymerase (PARP) cleavage. Additionally, the S. baicalensis root extract was found to have blocked vascular endothelial growth factor (VEGF)-induced migration and tube formation in human endothelial cells. Taken together, these results demonstrate that as a herbal product, the S. baicalensis root extract is a potential inhibitor of tumori- and angiogenesis and may be valuable in the development of pharmaceutical medications for the treatment of oral squamous cell carcinoma.

引用

页码：105 / 111

页数：7

共 27 条

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