LOW-DOSE CYTARABINE FOR ACUTE MYELOID-LEUKEMIA AND MYELODYSPLASTIC SYNDROMES - INVIVO AND INVITRO CYTOTOXICITY

被引：10
|
作者：
OSSENKOPPELE, GJ [1 ]
WIJERMANS, PW [1 ]
NAUTA, JJP [1 ]
HUIJGENS, PC [1 ]
LANGENHUIJSEN, MMAC [1 ]
机构：
[1] FREE UNIV AMSTERDAM HOSP,DEPT MED STAT,1081 HV AMSTERDAM,NETHERLANDS
来源：
EUROPEAN JOURNAL OF CANCER | 1991年 / 27卷 / 07期
关键词：
D O I：
10.1016/0277-5379(91)90130-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
14 patients with acute myeloid leukaemia (AML) and 7 with myelodysplastic syndrome (MDS) were treated with cytarabine in low dosage. In AML a complete remission rate of 43% was found and in all patients profound cytopenia was noticed without any sign of maturation induction. In MDS no effect of low-dose cytarabine could be detected. We also studied the effect of low-dose cytarabine in vitro in freshly isolated leukaemic cells of 10 patients with AML. Maturation induction was measured by a comprehensive panel of quantitative and qualitative markers of maturation. No differentiation inducing effect of low-dose cytarabine could be found. We conclude on the basis of our own results and after reviewing the literature that low-dose cytarabine exerts its effect by cytotoxicity instead of maturation induction.
引用
收藏
页码：842 / 845
页数：4
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