REACTIVE OXYGEN SPECIES AND ANTIOXIDANT VITAMINS - MECHANISMS OF ACTION

被引：341

作者：

FREI, B ^{[1
]}

机构：

[1] BOSTON UNIV, SCH MED, WHITAKER CARDIOVASC INST, DEPT BIOCHEM, BOSTON, MA 02118 USA

来源：

AMERICAN JOURNAL OF MEDICINE | 1994年 / 97卷

关键词：

D O I：

10.1016/0002-9343(94)90292-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article is a brief overview of the mechanisms of production of reactive oxygen species in biologic systems, and the various antioxidant defense systems that provide protection against oxidative damage to biologic macromolecules. The mechanisms of Lipid peroxidation and antioxidant protection are explained using a specific example, viz., oxidative modification of human low density lipoprotein and its prevention by vitamin C, vitamin E, and beta-carotene.

引用

页码：S5 / S13

页数：9

共 29 条

[1] URIC-ACID PROVIDES AN ANTIOXIDANT DEFENSE IN HUMANS AGAINST OXIDANT-CAUSED AND RADICAL-CAUSED AGING AND CANCER - A HYPOTHESIS [J].

AMES, BN ;

CATHCART, R ;

SCHWIERS, E ;

HOCHSTEIN, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :6858-6862

[2] OXIDANTS, ANTIOXIDANTS, AND THE DEGENERATIVE DISEASES OF AGING [J].

AMES, BN ;

SHIGENAGA, MK ;

HAGEN, TM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :7915-7922

[3] CELLULAR PRODUCTION OF HYDROGEN-PEROXIDE [J].

BOVERIS, A ;

CHANCE, B ;

OSHINO, N .

BIOCHEMICAL JOURNAL, 1972, 128 (03) :617-&

[4] BIOKINETICS OF DIETARY RRR-ALPHA-TOCOPHEROL IN THE MALE GUINEA-PIG AT 3 DIETARY LEVELS OF VITAMIN-C AND 2 LEVELS OF VITAMIN-E - EVIDENCE THAT VITAMIN-C DOES NOT SPARE VITAMIN-E INVIVO [J].

BURTON, GW ;

WRONSKA, U ;

STONE, L ;

FOSTER, DO ;

INGOLD, KU .

LIPIDS, 1990, 25 (04) :199-210

[5] BETA-CAROTENE - AN UNUSUAL TYPE OF LIPID ANTIOXIDANT [J].

BURTON, GW ;

INGOLD, KU .

SCIENCE, 1984, 224 (4649) :569-573

[6] THE ROLE OF LIPID-PEROXIDATION AND ANTIOXIDANTS IN OXIDATIVE MODIFICATION OF LDL [J].

ESTERBAUER, H ;

GEBICKI, J ;

PUHL, H ;

JURGENS, G .

FREE RADICAL BIOLOGY AND MEDICINE, 1992, 13 (04) :341-390

[7]

FREI B, 1993, J LIPID RES, V34, P2135

[8] ASCORBIC-ACID PROTECTS LIPIDS IN HUMAN PLASMA AND LOW-DENSITY-LIPOPROTEIN AGAINST OXIDATIVE DAMAGE [J].

FREI, B .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1991, 54 (06) :S1113-S1118

[9] ANTIOXIDANT DEFENSES AND LIPID-PEROXIDATION IN HUMAN-BLOOD PLASMA [J].

FREI, B ;

STOCKER, R ;

AMES, BN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (24) :9748-9752

[10]

Frei B., 1994, NATURAL ANTIOXIDANTS

← 1 2 3 →