EVALUATION OF BLOOD-SAMPLING FOR THE MEASUREMENT OF TISSUE-TYPE PLASMINOGEN-ACTIVATOR (T-PA) AND PLASMINOGEN-ACTIVATOR INHIBITOR ACTIVITY (PAI-1)

被引：1

作者：

VANDERHEIDE, YT ^{[1
]}

MORRIEN, W ^{[1
]}

VANDENENDE, A ^{[1
]}

机构：

[1] UNIV AMSTERDAM,ACAD MED CTR,CTR HEMOSTASIS THROMBOSIS ATHEROSCLEROSIS & INFLA,AMSTERDAM,NETHERLANDS

来源：

FIBRINOLYSIS | 1994年 / 8卷

关键词：

ANTICOAGULANTS; TISSUE-TYPE PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR INHIBITOR ACTIVITY;

D O I：

10.1016/0268-9499(94)90281-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We evaluated the effect of blood sampling in different anticoagulants on the measurement of t-PA antigen/activity and PAI-1 activity. Blood collection at acid pH (pH 5.9: Stabilyte tubes) yielded higher t-PA activity values (median 0.75 IU/ml, 0.46-1.19) than collection in citrate (median 0.04 IU/ml, 0.01-0.14) or in anticoagulant containing protease inhibitors (median 0.20 IU/ml, 0.02-0.41), No significant effects were seen in the levels of t-PA antigen with the different anticoagulants. For PAI-1 activity determination citrated plasma is preferable to Stabilyte plasma.

引用

页码：152 / 153

页数：2