SYNTHESIS OF N-(2-DEOXY-BETA-D-RIBOSYL) 4-THIOMETHYLINDOLE - A PURINE SURROGATE FOR INCORPORATION INTO OLIGONUCLEOTIDES

被引：11
作者：
COLEMAN, RS
DONG, Y
ARTHUR, JC
机构：
[1] Department of Chemistry, Biochemistry University of South Carolina, Columbia
来源：
TETRAHEDRON LETTERS | 1993年 / 34卷 / 43期
关键词：
D O I：
10.1016/S0040-4039(00)91816-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Efficient, high-yielding syntheses of S-acetyl-N-(2-deoxy-beta-D-ribosyl) 4 thiomethylindole (9) and the corresponding 5'-O-trityl-3'-0-phosphoramidite ester 11 are reported, suitable for direct incorporation into oligodeoxynucleotides by standard solid-phase synthesis techniques.
引用
收藏
页码：6867 / 6870
页数：4
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