INFLUENCE OF AMOROLFINE ON THE MORPHOLOGY OF CANDIDA-ALBICANS AND TRICHOPHYTON-MENTAGROPHYTES

被引：2
|
作者：
MULLER, J [1 ]
POLAKWYSS, A [1 ]
MELCHINGER, W [1 ]
机构：
[1] F HOFFMANN LA ROCHE & CO LTD,CH-4002 BASEL,SWITZERLAND
来源：
DERMATOLOGY | 1992年 / 184卷
关键词：
CANDIDA-ALBICANS; TRICHOPHYTON-MENTAGROPHYTES; ULTRASTRUCTURE; TRANSMISSION ELECTRON MICROSCOPY; AMOROLFINE;
D O I：
10.1159/000247589
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Amorolfine applied in concentrations of 0.1-100-mu-g/ml causes considerable damage to the ultrastructure of Candida albicans and Trichophyton mentagrophytes: electron-lucent areas appear in the cytoplasm. Extracytoplasmic membrane vesicles are formed and deposited in the cell wall. Starved fungal cells, with normal ultrastructure, can be found. Lysed, dead cells demonstrate the process of severe ultrastructural damage. T. mentagrophytes cell walls especially increase in thickness. The feature of the damage caused by amorolfine is comparable to that produced by azole antifungals.
引用
收藏
页码：8 / 17
页数：10
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