Membrane bile acid receptor TGR5 - a new target in the study of metabolic, inflammatory and neoplastic diseases

被引：0

作者：

Drapkina, O. M. ^{[1
]}

Fomicheva, E. I. ^{[1
]}

机构：

[1] State Res Ctr Prevent Med, Petroverigsky Per 10, Moscow 101990, Russia

来源：

RATIONAL PHARMACOTHERAPY IN CARDIOLOGY | 2016年 / 12卷 / 03期

关键词：

TGR5; bile acids; metabolic disorders; obesity; inflammation; carcinogenesis;

D O I：

10.20996/1819-6446-2016-12-3-344-350

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

TGR5 are G-protein-linked, membrane bile acids receptors that widely express in tissues of animals and humans. Namely tissue localization of TGR5 determines biological effects of activation of these receptors. This review focuses on the role of TGR5 as a new pharmacological target for the treatment of patients with metabolic syndrome, diabetes, obesity, atherosclerosis, liver disease and cancer processes.

引用

页码：344 / 350

页数：7

共 47 条

[1] The TGR5 receptor mediates bile acid-induced itch and analgesia [J].

Alemi, Farzad ;

Kwon, Edwin ;

Poole, Daniel P. ;

Lieu, TinaMarie ;

Lyo, Victoria ;

Cattaruzza, Fiore ;

Cevikbas, Ferda ;

Steinhoff, Martin ;

Nassini, Romina ;

Materazzi, Serena ;

Guerrero-Alba, Raquel ;

Valdez-Morales, Eduardo ;

Cottrell, Graeme S. ;

Schoonjans, Kristina ;

Geppetti, Pierangelo ;

Vanner, Stephen J. ;

Bunnett, Nigel W. ;

Corvera, Carlos U. .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (04) :1513-1530

[2] Carcinogenicity of deoxycholate, a secondary bile acid [J].

Bernstein, Carol ;

Holubec, Hana ;

Bhattacharyya, Achyut K. ;

Huy Nguyen ;

Payne, Claire M. ;

Zaitlin, Beryl ;

Bernstein, Harris .

ARCHIVES OF TOXICOLOGY, 2011, 85 (08) :863-871

[3] The Expression and the Cellular Distribution of the Tight Junction Proteins Are Altered in Irritable Bowel Syndrome Patients With Differences According to the Disease Subtype [J].

Bertiaux-Vandaele, Nathalie ;

Youmba, Stephanie Beutheu ;

Belmonte, Liliana ;

Lecleire, Stephane ;

Antonietti, Michel ;

Gourcerol, Guillaume ;

Leroi, Anne-Marie ;

Dechelotte, Pierre ;

Menard, Jean-Francois ;

Ducrotte, Philippe ;

Coeffier, Moise .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2011, 106 (12) :2165-2173

[4]

Bunnett N, 2012, GASTROENTEROLOGY, V142, pS148

[5] DIFFERENTIAL-EFFECTS OF CHENODEOXYCHOLIC AND URSODEOXYCHOLIC ACIDS ON INTERLEUKIN-1, INTERLEUKIN-6 AND TUMOR-NECROSIS-FACTOR-ALPHA PRODUCTION BY MONOCYTES [J].

CALMUS, Y ;

GUECHOT, J ;

PODEVIN, P ;

BONNEFIS, MT ;

GIBOUDEAU, J ;

POUPON, R .

HEPATOLOGY, 1992, 16 (03) :719-723

[6] Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders [J].

Camilleri, M. ;

Vazquez-Roque, M. I. ;

Carlson, P. ;

Burton, D. ;

Wong, B. S. ;

Zinsmeister, A. R. .

NEUROGASTROENTEROLOGY AND MOTILITY, 2011, 23 (11) :995-E458

[7] Expression of bile acid receptor TGR5 in gastric adenocarcinoma [J].

Cao, Weibiao ;

Tian, Wei ;

Hong, Jie ;

Li, Dan ;

Tavares, Rosemarie ;

Noble, Lelia ;

Moss, Steven F. ;

Resnick, Murray B. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2013, 304 (04) :G322-G327

[8] RETRACTED: Deficiency of G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Enhances Chemically Induced Liver Carcinogenesis (Retracted article. See vol. 58, pg. 1194, 2013) [J].

Chen, Wei-Dong ;

Yu, Donna ;

Forman, Barry M. ;

Huang, Wendong ;

Wang, Yan-Dong .

HEPATOLOGY, 2013, 57 (02) :656-666

[9] The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis [J].

Cipriani, Sabrina ;

Mencarelli, Andrea ;

Chini, Maria Giovanna ;

Distrutti, Eleonora ;

Renga, Barbara ;

Bifulco, Giuseppe ;

Baldelli, Franco ;

Donini, Annibale ;

Fiorucci, Stefano .

PLOS ONE, 2011, 6 (10)

[10] The role of bile acids in carcinogenesis [J].

Debruyne, PR ;

Bruyneel, EA ;

Li, XD ;

Zimber, A ;

Gespach, C ;

Mareel, MM .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2001, 480 :359-369

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