EXPRESSION OF FAMILIAL HYPERCHOLESTEROLEMIA GENE IN HETEROZYGOTES - MECHANISM FOR A DOMINANT DISORDER IN MAN

被引：224
作者：
BROWN, MS [1 ]
GOLDSTEIN, JL [1 ]
机构：
[1] UNIV TEXAS, SW MED SCH, DEPT INTERN MED, DALLAS, TX 75235 USA
来源：
SCIENCE | 1974年 / 185卷 / 4145期
关键词：
D O I：
10.1126/science.185.4145.61
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：61 / 63
页数：3
相关论文
共 14 条
[1]  
Brown M. P., IN PRESS
[2]  
BROWN MS, 1974, J BIOL CHEM, V249, P789
[3]   REGULATION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE-ACTIVITY IN HUMAN FIBROBLASTS BY LIPOPROTEINS [J].
BROWN, MS ;
DANA, SE ;
GOLDSTEIN, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (07) :2162-2166
[4]   FAMILIAL HYPERCHOLESTEROLEMIA - DEFECTIVE BINDING OF LIPOPROTEINS TO CULTURED FIBROBLASTS ASSOCIATED WITH IMPAIRED REGULATION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE-ACTIVITY [J].
BROWN, MS ;
GOLDSTEIN, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (03) :788-792
[5]  
FRASER FC, 1969, CONGENITAL MALFORMAT
[6]   FAMILIAL HYPERCHOLESTEROLEMIA - IDENTIFICATION OF A DEFECT IN REGULATION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE-ACTIVITY ASSOCIATED WITH OVERPRODUCTION OF CHOLESTEROL [J].
GOLDSTEIN, JL ;
BROWN, MS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (10) :2804-2808
[7]  
GOLDSTEIN JL, 1974, AM J HUM GENET, V26, P199
[8]  
GOLDSTEIN JL, IN PRESS
[9]  
GRUNDY SM, 1969, J LIPID RES, V10, P91
[10]   INHERITANCE OF ESSENTIAL FAMILIAL HYPERCHOLESTEROLEMIA [J].
KHACHADURIAN, AK .
AMERICAN JOURNAL OF MEDICINE, 1964, 37 (03) :402-&
12