IMPROVED SOLID-PHASE SYNTHESIS OF C-TERMINAL PEPTIDE ALDEHYDES

被引：80
|
作者：
FEHRENTZ, JA
PARIS, M
HEITZ, A
VELEK, J
LIU, CF
WINTERNITZ, F
MARTINEZ, J
机构：
[1] FAC PHARM MONTPELLIER,CNRS,CHIM & PHARMACOL MOLECULES INTERET BIOL LAB,F-34060 MONTPELLIER,FRANCE
[2] FAC PHARM MONTPELLIER,CNRS,UNITE MIXTE,F-34060 MONTPELLIER,FRANCE
来源：
TETRAHEDRON LETTERS | 1995年 / 36卷 / 43期
关键词：
D O I：
10.1016/0040-4039(95)01646-Y
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new linker based on the Weinreb amide was developed in order to synthesize from peptidyl-resin the corresponding aldehydic peptides by reduction with LiAlH4. This new reaction was tested with N-protected amino-residues and with tripeptides to obtain the corresponding aldehydes without racemisation.
引用
收藏
页码：7871 / 7874
页数：4
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