IMPROVED SOLID-PHASE SYNTHESIS OF C-TERMINAL PEPTIDE ALDEHYDES

被引：80

作者：

FEHRENTZ, JA

PARIS, M

HEITZ, A

VELEK, J

LIU, CF

WINTERNITZ, F

MARTINEZ, J

机构：

[1] FAC PHARM MONTPELLIER,CNRS,CHIM & PHARMACOL MOLECULES INTERET BIOL LAB,F-34060 MONTPELLIER,FRANCE

[2] FAC PHARM MONTPELLIER,CNRS,UNITE MIXTE,F-34060 MONTPELLIER,FRANCE

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 43期

关键词：

D O I：

10.1016/0040-4039(95)01646-Y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new linker based on the Weinreb amide was developed in order to synthesize from peptidyl-resin the corresponding aldehydic peptides by reduction with LiAlH4. This new reaction was tested with N-protected amino-residues and with tripeptides to obtain the corresponding aldehydes without racemisation.

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页码：7871 / 7874

页数：4

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