THE INFLUENCE OF 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN ON DIFFUSION RATES AND TRANSDERMAL DELIVERY OF HYDROCORTISONE

被引：28
|
作者：
LOFTSSON, T
FRIORIKSDOTTIR, H
INGVARSDOTTIR, G
JONSDOTTIR, B
SIGUROARDOTTIR, AM
机构：
[1] Department of Pharmacy, University of Iceland, IS-101, Reykjavík
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1994年 / 20卷 / 09期
关键词：
D O I：
10.3109/03639049409050210
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The influence of 2-hydroxypropyl-beta-cyclodextrin (HP beta CD) on the permeability of hydrocortisone through semi-permeable cellophane membrane and hairless mouse skin was investigated. When the hydrocortisone concentration was kept constant and the HP beta CD concentration in an aqueous vehicle was gradually increased the flux through the semi-permeable membrane was increased until all hydrocortisone had dissolved, after that the flux decreased with increasing HP beta CD concentration. A maximum flux was obtained when just enough HP beta CD was used to dissolve all the drug in the aqueous vehicle.
引用
收藏
页码：1699 / 1708
页数：10
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