EXPRESSION OF HUMAN ENDOGENOUS RETROVIRUS (HERV-K) IN CHRONIC MYELOID-LEUKEMIA

被引：25

作者：

BRODSKY, I

FOLEY, B

GILLESPIE, D

机构：

[1] Department of Neoplastic Diseases, Hahnemann University Hospital, Philadelphia, PA, Broad and Vine

来源：

LEUKEMIA & LYMPHOMA | 1993年 / 11卷

关键词：

EXPRESSION HERV-K; CML; LEUKEMIA HUMAN ENDOGENOUS RETROVIRUS;

D O I：

10.3109/10428199309047874

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have previously demonstrated the presence of a reverse transcriptase-like enzyme in retroviral particles from patients with essential thrombocythemia, polycythemia vera, and chronic myelogenous leukemia. It was subsequently shown that the human genome contains 50 copies of HERV-K. HERV-K is a human endogenous class I retroviral element that contains gag, pol, and env open reading frames. Using both reverse transcriptase-polymerase chain reaction and ribonuclease protection assays, it is demonstrated that the HERV-K pol is expressed in human blood leukocytes. The data indicates that this expression is restricted in CML white cells and is the result of gene regulation.

引用

页码：119 / 123

页数：5

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