THE ANTICOAGULANT ACTION OF PHOSPHOLIPASE-A FROM ERESUS-NIGER SPIDER VENOM

被引：12
|
作者：
USMANOV, PB
NURITOVA, FA
机构：
[1] Institute of Physiology and Biophysics, Uzbek Academy of Sciences, 700095 Tashkent
来源：
TOXICON | 1994年 / 32卷 / 05期
关键词：
D O I：
10.1016/0041-0101(94)90210-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Phospholipase A, named component EnPA, was isolated from Eresus niger spider venom. It was determined to be a single peptide chain with mel. wt of 13,000. Component EnPA showed high anticoagulant activity when the APTT was measured in spite of its low enzymatic activity (30 +/- 6 mu mol/min/mg). It was concluded that anticoagulant action of compound EnPA is due to inactivation of the procoagulant activity of phospholipids because of its high binding with them.
引用
收藏
页码：625 / 628
页数：4
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