HUMAN ASTROCYTES AND CYTOKINES - TUMOR-NECROSIS-FACTOR-ALPHA AND INTERFERON-GAMMA DO NOT PROMOTE ASTROCYTIC PROLIFERATION

被引：15

作者：

MORETTO, G ^{[1
]}

YOO, A ^{[1
]}

KIM, SU ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA, DEPT MED, DIV NEUROL, VANCOUVER V6T 1W5, BC, CANADA

来源：

NEUROSCIENCE LETTERS | 1993年 / 151卷 / 01期

关键词：

ASTROCYTE; BROMODEOXYURIDINE; CYTOKINE; HUMAN; INTERFERON-GAMMA; TUMOR NECROSIS FACTOR-ALPHA;

D O I：

10.1016/0304-3940(93)90034-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Astrocyte cell cultures were established from human fetal brains and exposed to human recombinant tumor necrosis factor alpha (TNFalpha) and human recombinant interferon gamma (IFNgamma), and the proliferative response was assessed by bromodeoxyuridine-immunostaining technique. TNFalpha showed an inhibitory activity, while IFNgamma induced a slight increase in the number of astrocytes undergoing cell division. However, in both experiments differences were not statistically significant. Previous studies have demonstrated that TNFalpha and IFNgamma are potent mitogens for adult astrocytes in both in vivo and in vitro conditions. Our results suggest that in developing brain the immunomodulatory activity of cytokines, TNFalpha and IFNgamma, is different from that observed in adult brain.

引用

页码：17 / 20

页数：4

共 15 条

[1] HUMAN ASTROCYTES PROLIFERATE IN RESPONSE TO TUMOR-NECROSIS-FACTOR-ALPHA [J].

BARNA, BP ;

ESTES, ML ;

JACOBS, BS ;

HUDSON, S ;

RANSOHOFF, RM .

JOURNAL OF NEUROIMMUNOLOGY, 1990, 30 (2-3) :239-243

[2] DIFFERENCES BETWEEN ADULT AND NEONATAL RATS IN THEIR ASTROGLIAL RESPONSE TO SPINAL-INJURY [J].

BARRETT, CP ;

DONATI, EJ ;

GUTH, L .

EXPERIMENTAL NEUROLOGY, 1984, 84 (02) :374-385

[3] TUMOR NECROSIS FACTOR-ALPHA ENHANCES INTERFERON-GAMMA-MEDIATED CLASS-II ANTIGEN EXPRESSION ON ASTROCYTES [J].

BENVENISTE, EN ;

SPARACIO, SM ;

BETHEA, JR .

JOURNAL OF NEUROIMMUNOLOGY, 1989, 25 (2-3) :209-219

[4] ASTROCYTES PRESENT MYELIN BASIC-PROTEIN TO ENCEPHALITOGENIC T-CELL LINES [J].

FONTANA, A ;

FIERZ, W ;

WEKERLE, H .

NATURE, 1984, 307 (5948) :273-276

[5] CYTOKINES AND NEUROPATHOLOGY [J].

MORGANTIKOSSMANN, MC ;

KOSSMANN, T ;

WAHL, SM .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (07) :286-291

[6]

RAFF MC, 1983, J NEUROSCI, V3, P1289

[7] CYTOKINE-INDUCED EXPRESSION OF INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) IN CULTURED HUMAN OLIGODENDROCYTES AND ASTROCYTES [J].

SATOH, JI ;

KASTRUKOFF, LF ;

KIM, SU .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1991, 50 (03) :215-226

[8] PRODUCTION OF TUMOR NECROSIS FACTOR-ALPHA BY MICROGLIA AND ASTROCYTES IN CULTURE [J].

SAWADA, M ;

KONDO, N ;

SUZUMURA, A ;

MARUNOUCHI, T .

BRAIN RESEARCH, 1989, 491 (02) :394-397

[9] Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor (Reprinted from AAAS, vol 257, pg 809-813, 1992) [J].

Schindler, Chris ;

Shuai, Ke ;

Prezioso, Vincent R. ;

Darnell, James E., Jr. .

JOURNAL OF IMMUNOLOGY, 2011, 187 (11) :5489-5493

[10] TUMOR NECROSIS FACTOR-INDUCED PROLIFERATION OF ASTROCYTES FROM MATURE BRAIN IS ASSOCIATED WITH DOWN-REGULATION OF GLIAL FIBRILLARY ACIDIC PROTEIN MESSENGER-RNA [J].

SELMAJ, K ;

SHAFITZAGARDO, B ;

AQUINO, DA ;

FAROOQ, M ;

RAINE, CS ;

NORTON, WT ;

BROSNAN, CF .

JOURNAL OF NEUROCHEMISTRY, 1991, 57 (03) :823-830

← 1 2 →