REGULATION OF CU,ZN-SUPEROXIDE AND MN-SUPEROXIDE DISMUTASE TRANSCRIPTION IN SACCHAROMYCES-CEREVISIAE

被引：49

作者：

GALIAZZO, F ^{[1
]}

LABBEBOIS, R ^{[1
]}

机构：

[1] UNIV PARIS 07,BIOCHIM PORPHYRINES LAB,INST JACQUES MONOD,2 PL JUSSIEU,F-75221 PARIS 05,FRANCE

来源：

FEBS LETTERS | 1993年 / 315卷 / 02期

关键词：

SUPEROXIDE DISMUTASE; PARAQUAT; OXYGEN AND HEME; TRANSCRIPTIONAL REGULATION; SACCHAROMYCES-CEREVISIAE;

D O I：

10.1016/0014-5793(93)81162-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of Cu,Zn- and Mn-superoxide dismutases (SOD) was investigated by Northern blotting and gene fusions of SOD1 and SOD2 promoters with the beta-galactosidase reporter gene. Cu,ZnSOD expression was increased 3-fold under glucose derepressing conditions, and 4- to 6-fold by oxygen or heme deficiency. MnSOD expression was increased 5-fold by glucose derepression, and decreased 8- to 10-fold by anaerobiosis and 4- to 5-fold by heme deficiency. Induction by paraquat was modest, about 50% for SOD1 and 100% for SOD2; it was apparently independent of the respiratory chain function.

引用

页码：197 / 200

页数：4

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