PHASE-I STUDY OF ANTILIPOPOLYSACCHARIDE HUMAN MONOCLONAL-ANTIBODY MAB-T88

被引：12

作者：

DAIFUKU, R ^{[1
]}

HAENFTLING, K ^{[1
]}

YOUNG, J ^{[1
]}

GROVES, ES ^{[1
]}

TURRELL, C ^{[1
]}

MEYERS, FJ ^{[1
]}

机构：

[1] CHIRON CORP,1400 53RD ST,EMERYVILLE,CA 94608

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 10期

关键词：

D O I：

10.1128/AAC.36.10.2349

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Monoclonal antibody MAB-T88 is a human monoclonal immunoglobulin M antibody directed at the lipopolysaccharide of gram-negative bacteria. In this study, nine patients who were expected to become neutropenic from antineoplastic chemotherapy received an infusion of MAB-T88, three patients at each of three doses: 1, 4, and 8 mg/kg of body weight. MAB-T88 was shown to be safe, with an effective half-life in plasma of 25.4 h, and no patient developed immunoglobulin G antibody to MAB-T88.

引用

收藏

页码：2349 / 2351

页数：3

相关论文

共 50 条

[41] CHARACTERIZATION OF A MONOCLONAL-ANTIBODY (MAB) WITH BOTH AGONISTIC AND ANTAGONISTIC EFFECTS ON T-CELL ACTIVATION [J].

ONO, K ;

SHEVACH, EM .

FASEB JOURNAL, 1988, 2 (04) :A870-A870

[42] PHASE-I STUDY OF A MURINE MONOCLONAL ANTI-LIPID-A ANTIBODY IN BACTEREMIC AND NONBACTEREMIC PATIENTS [J].

HARKONEN, S ;

SCANNON, P ;

MISCHAK, RP ;

SPITLER, LE ;

FOXALL, C ;

KENNEDY, D ;

GREENBERG, R .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (05) :710-716

[43] MONOCLONAL-ANTIBODY (MAB) ANALYSIS OF BENZOPYRENE (BP)-INDUCED FETAL T-CELL ANTIGENS [J].

HERD, Z ;

HENNINGSEN, G .

FASEB JOURNAL, 1991, 5 (06) :A1689-A1689

[44] PHASE-I/II STUDY OF MONOCLONAL-ANTIBODY AGAINST LEWIS-Y HAPTEN IN RELAPSED SMALL-CELL LUNG-CANCER [J].

STAHEL, RA ;

LACROIX, H ;

SCULIER, JP ;

MORANT, R ;

RICHNER, J ;

JANZEK, E ;

LOIBNER, H ;

BLYTHMAN, H .

ANNALS OF ONCOLOGY, 1992, 3 (04) :319-320

[45] HUMAN ANTI-IDIOTYPE ANTIBODY-RESPONSE TO ANTI-CEA MURINE MONOCLONAL-ANTIBODY (MAB) [J].

DEJAGER, RL ;

LOSMAN, MJ ;

TRAUB, UC ;

DEJAGER, PL ;

SHARKEY, RM ;

HANSEN, HJ ;

GOLDENBERG, DM .

PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1988, 29 :377-377

[46] CHARACTERIZATION OF A MONOCLONAL-ANTIBODY MITOGENIC FOR HUMAN T-CELLS [J].

HAMMARSTROM, ML ;

BERZINS, T ;

AGUILARSANTELISES, M ;

ANDERSSON, G ;

KROMNOW, A ;

HAMMARSTROM, S ;

PERLMANN, P .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1986, 24 (04) :464-464

[47] A MONOCLONAL-ANTIBODY BLOCKING HUMAN T-CELL FUNCTION [J].

REINHERZ, EL ;

HUSSEY, RE ;

SCHLOSSMAN, SF .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1980, 10 (10) :758-762

[48] THE EFFECT OF UNLABELED MONOCLONAL-ANTIBODY (MAB) ON THE BIODISTRIBUTION OF I-131 ANTIIDIOTYPE MAB IN MURINE B-CELL LYMPHOMA [J].

SCHIELE, J ;

KNOX, SJ ;

RUEHL, W ;

GORIS, ML .

RADIOTHERAPY AND ONCOLOGY, 1992, 24 (03) :169-176

[49] CMV - PROPHYLAXIS WITH A NEUTRALIZING HUMAN ANTI CMV MONOCLONAL-ANTIBODY - PRELIMINARY-RESULTS OF A PHASE-I TRIAL IN BONE-MARROW TRANSPLANT RECIPIENTS [J].

AULITZKY, WE ;

TILG, H ;

NIEDERWIESER, D ;

SCHULZ, T ;

SCRIBA, M ;

STERN, M ;

DIERICH, M ;

HUBER, C .

BLUT, 1987, 55 (04) :219-219

[50] RADIOIMMUNODETECTION OF HUMAN-TUMOR XENOGRAFTS BY MONOCLONAL-ANTIBODY (MAB) F(AB')2 FRAGMENTS [J].

HERLYN, D ;

POWE, J ;

MUNZ, DL ;

HERLYN, M ;

ALAVI, A ;

SRIVASTAVA, SC ;

KOPROWSKI, H .

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1985, 189 (APR-) :64-NUCL

← 1 2 3 4 5 →