PHASE-I STUDY OF ANTILIPOPOLYSACCHARIDE HUMAN MONOCLONAL-ANTIBODY MAB-T88

被引：12

作者：

DAIFUKU, R ^{[1
]}

HAENFTLING, K ^{[1
]}

YOUNG, J ^{[1
]}

GROVES, ES ^{[1
]}

TURRELL, C ^{[1
]}

MEYERS, FJ ^{[1
]}

机构：

[1] CHIRON CORP,1400 53RD ST,EMERYVILLE,CA 94608

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 10期

关键词：

D O I：

10.1128/AAC.36.10.2349

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Monoclonal antibody MAB-T88 is a human monoclonal immunoglobulin M antibody directed at the lipopolysaccharide of gram-negative bacteria. In this study, nine patients who were expected to become neutropenic from antineoplastic chemotherapy received an infusion of MAB-T88, three patients at each of three doses: 1, 4, and 8 mg/kg of body weight. MAB-T88 was shown to be safe, with an effective half-life in plasma of 25.4 h, and no patient developed immunoglobulin G antibody to MAB-T88.

引用

页码：2349 / 2351

页数：3

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