STRUCTURE OF THE CONSTANT AND 3' UNTRANSLATED REGIONS OF THE MURINE GAMMA-2B HEAVY-CHAIN MESSENGER-RNA

被引：58

作者：

TUCKER, PW ^{[1
]}

MARCU, KB ^{[1
]}

SLIGHTOM, JL ^{[1
]}

BLATTNER, FR ^{[1
]}

机构：

[1] UNIV WISCONSIN,GENET LAB,MADISON,WI 53206

来源：

SCIENCE | 1979年 / 206卷 / 4424期

关键词：

D O I：

10.1126/science.117548

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The complete coding sequence for the constant region of the mouse γ2b immunoglobulin heavy chain and the 3′ untranslated region has been determined. The coding portion of the sequence is 1008 nucleotides long (amino acid residues 114 to 449), and the 3′ noncoding region contains 102 nucleotides preceeding the polyadenylate. An extra carboxyl-terminal lysine residue which had not been observed in the γ2b or other γ subclass protein sequences occurs in the nucleotide sequence and is probably processed posttranslationally. A 17-nucleotide sequence occurs with slight variation twice in CH1 and once in CH2 domains in the same relative location but with different translational phase. This sequence may be the site of crossover in a γ2b · γ2a heavy chain variant, an indication of possible recombinational activity of some kind. Copyright © 1979 AAAS.

引用

页码：1299 / 1303

页数：5

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